CMap Candidate Details

Structure:
CMap ID: C00243
Pert ID: BRD-A09472452
Compound Name: flecainide
Targets: SCN5A
MoA: Sodium channel blocker
SMILES: FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC1CCCCN1
InchiKey: DJBNUMBKLMJRSA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5494 BRD-A09472452 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5823 BRD-A09472452 HEPG2 10 uM 6 h 0.25 1.04 0.14 0.0 0.0 0.0
42169 BRD-A09472452 ASC 10 uM 24 h -0.26 -1.06 0.26 0.0 0.0 0.0
43373 BRD-A09472452 NPC 10 uM 24 h 0.25 1.05 0.16 -0.25 -0.83 0.17
43688 BRD-A09472452 PHH 10 uM 24 h 0.27 1.11 0.25 0.27 0.96 0.34
49930 BRD-A09472452 A549 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.21 1.24
50094 BRD-A09472452 HA1E 10 uM 6 h 0.0 0.0 0.0 0.35 1.24 1.28
50448 BRD-A09472452 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50625 BRD-A09472452 MCF??7.00 10 uM 24 h 0.18 0.77 0.0 -0.38 -1.27 1.41
50880 BRD-A09472452 PC3 10 uM 6 h 0.0 0.0 0.0 0.32 1.15 0.88
50971 BRD-A09472452 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90986 BRD-A09472452 HUH7 8 uM 72 h -0.29 -1.19 0.55 0.0 0.0 0.0
121348 BRD-A09472452 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.23 1.27
129246 BRD-A09472452 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129276 BRD-A09472452 HELA 0.74 uM 3 h 0.0 0.0 0.0 -0.33 -1.12 0.93
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).