CMap Candidate Details

Structure:
CMap ID: C24321
Pert ID: BRD-K68870568
Compound Name: flumatinib
Targets: ABL1; PDGFRB
MoA: Abl kinase inhibitor
SMILES: CN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2cnc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
InchiKey: BJCJYEYYYGBROF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95337 BRD-K68870568 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95373 BRD-K68870568 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95465 BRD-K68870568 U2OS 1.11 uM 6 h -0.31 -1.27 0.74 0.0 0.0 0.0
96693 BRD-K68870568 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126739 BRD-K68870568 HT29 10 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.43
126768 BRD-K68870568 JURKAT 10 uM 24 h -0.24 -0.98 0.12 0.3 1.07 0.63
126800 BRD-K68870568 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.99
126878 BRD-K68870568 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126940 BRD-K68870568 THP1 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.93
134671 BRD-K68870568 A375 2.22 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
134722 BRD-K68870568 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134759 BRD-K68870568 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134792 BRD-K68870568 HELA 0.08 uM 24 h 0.0 0.0 0.0 -0.2 -0.69 0.02
134855 BRD-K68870568 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134988 BRD-K68870568 YAPC 0.74 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).