CMap Candidate Details

Structure:
CMap ID: C24368
Pert ID: BRD-K69023402
Compound Name: thapsigargin
Targets: ATP2A1
MoA: ATPase inhibitor
SMILES: CCCCCCCC(=O)O[C@@H]1[C@@H](OC(=O)/C(=CC)/C)C(=C2[C@@H]3OC(=O)[C@@](C)(O)[C@@]3(O)[C@H](C[C@](C)(OC(=O)C)[C@@H]12)OC(=O)CCC)C
InchiKey: IXFPJGBNCFXKPI-FSIHEZPISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6798 BRD-K69023402 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7023 BRD-K69023402 A549 10 uM 24 h -0.23 -0.94 0.08 -0.38 -1.29 1.53
7353 BRD-K69023402 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
7711 BRD-K69023402 HCC515 10 uM 6 h 0.0 0.0 0.0 0.24 0.86 0.15
7910 BRD-K69023402 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
88576 BRD-K69023402 VCAP 2.22 uM 6 h 0.0 0.0 0.0 -0.46 -1.56 15.65
90630 BRD-K69023402 HCT116 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90648 BRD-K69023402 MCF10A 10 uM 24 h 0.24 1.0 0.1 0.0 0.0 0.0
98068 BRD-K69023402 P1A82 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
98821 BRD-K69023402 NPC 10 uM 6 h -0.18 -0.76 0.0 0.0 0.0 0.0
98926 BRD-K69023402 NEU 10 uM 24 h 0.23 0.94 0.06 -0.26 -0.89 0.26
99395 BRD-K69023402 U2OS 8 uM 6 h -0.19 -0.81 0.0 0.0 0.0 0.0
119657 BRD-K69023402 HEPG2 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119742 BRD-K69023402 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119785 BRD-K69023402 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
119819 BRD-K69023402 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).