CMap Candidate Details

Structure:
CMap ID: C24397
Pert ID: BRD-K69116396
Compound Name: sertindole
Targets: DRD2; HTR2A; HTR2C
MoA: Dopamine receptor antagonist; Serotonin receptor antagonist
SMILES: Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2cc(Cl)ccc12
InchiKey: GZKLJWGUPQBVJQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126626 BRD-K69116396 A375 10 uM 24 h 0.27 1.13 0.29 0.38 1.34 1.72
126648 BRD-K69116396 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126670 BRD-K69116396 HA1E 10 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
126688 BRD-K69116396 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.2
126711 BRD-K69116396 HELA 10 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.08
126738 BRD-K69116396 HT29 10 uM 24 h -0.16 -0.66 0.0 0.24 0.86 0.16
126767 BRD-K69116396 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126799 BRD-K69116396 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126834 BRD-K69116396 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.42 2.53
126877 BRD-K69116396 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.38 1.36 1.72
126939 BRD-K69116396 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126986 BRD-K69116396 YAPC 10 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
134854 BRD-K69116396 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134959 BRD-K69116396 PC3 2.22 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).