CMap Candidate Details

Structure:
CMap ID: C24425
Pert ID: BRD-K69236721
Compound Name: VX-809
Targets: --
MoA: --
SMILES: Cc1ccc(NC(=O)C2(CC2)c2ccc3OC(F)(F)Oc3c2)nc1-c1cccc(c1)C(O)=O
InchiKey: UFSKUSARDNFIRC-UHFFFAOYSA-N
Compound Aliases: lumacaftor

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126358 BRD-K69236721 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.32
126375 BRD-K69236721 A549 10 uM 24 h 0.0 0.0 0.0 0.23 0.8 0.08
126399 BRD-K69236721 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
126427 BRD-K69236721 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126574 BRD-K69236721 PC3 10 uM 24 h 0.26 1.08 0.21 0.31 1.11 0.72
134424 BRD-K69236721 HELA 0.25 uM 24 h -0.24 -1.0 0.15 -0.31 -1.06 0.73
134456 BRD-K69236721 HT29 0.25 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
134493 BRD-K69236721 HUVEC 0.08 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
134534 BRD-K69236721 MCF10A 0.74 uM 24 h 0.3 1.23 0.5 0.34 1.19 1.05
134564 BRD-K69236721 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
134593 BRD-K69236721 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134649 BRD-K69236721 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).