CMap Candidate Details

Structure:
CMap ID: C00245
Pert ID: BRD-A09533288
Compound Name: verapamil
Targets: CACNA1C; CACNA1D; CACNA1S; CACNA1G
MoA: Calcium channel blocker
SMILES: COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InchiKey: SGTNSNPWRIOYBX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1431 BRD-A09533288 NPC 12.5 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.78
9264 BRD-A09533288 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9567 BRD-A09533288 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10158 BRD-A09533288 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10380 BRD-A09533288 HCT116 10 uM 6 h 0.28 1.15 0.32 0.0 0.0 0.0
10649 BRD-A09533288 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11317 BRD-A09533288 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11636 BRD-A09533288 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11887 BRD-A09533288 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12644 BRD-A09533288 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13126 BRD-A09533288 U937 10 uM 6 h 0.21 0.88 0.01 0.0 0.0 0.0
13522 BRD-A09533288 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44473 BRD-A09533288 A549 10 uM 24 h -0.26 -1.07 0.27 -0.25 -0.85 0.19
44744 BRD-A09533288 ASC 10 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.66
46176 BRD-A09533288 PHH 10 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
46492 BRD-A09533288 SKB 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.76
91038 BRD-A09533288 HUH7 8 uM 72 h -0.29 -1.21 0.58 -0.28 -0.95 0.4
98967 BRD-A09533288 NEU 10 uM 6 h -0.26 -1.09 0.33 0.0 0.0 0.0
121155 BRD-A09533288 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121290 BRD-A09533288 MCF??7.00 1.11 uM 24 h 0.38 1.59 1.52 0.3 1.08 0.65
121321 BRD-A09533288 PC3 0.04 uM 24 h 0.31 1.28 0.61 0.0 0.0 0.0
121350 BRD-A09533288 YAPC 10 uM 24 h 0.29 1.22 0.48 -0.38 -1.29 1.57
129256 BRD-A09533288 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129264 BRD-A09533288 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129304 BRD-A09533288 HT29 2.22 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).