CMap Candidate Details

Structure:
CMap ID: C24538
Pert ID: BRD-K69556541
Compound Name: ryanodine
Targets: RYR1
MoA: Calcium channel blocker
SMILES: CC(C)[C@]1(O)[C@@H](OC(=O)c2ccc[nH]2)[C@]3(O)[C@]4(O)[C@]1(C)[C@]5(O)C[C@@]3(C)[C@@]6(O)CC[C@H](C)[C@@H](O)[C@]46O5
InchiKey: JJSYXNQGLHBRRK-RGPFZKLOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1611 BRD-K69556541 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1956 BRD-K69556541 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2255 BRD-K69556541 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2737 BRD-K69556541 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41832 BRD-K69556541 A375 10 uM 6 h -0.2 -0.83 0.0 0.0 0.0 0.0
41974 BRD-K69556541 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42452 BRD-K69556541 ASC 10 uM 24 h -0.24 -0.99 0.13 0.26 0.91 0.24
42764 BRD-K69556541 HEPG2 10 uM 6 h -0.23 -0.96 0.1 -0.19 -0.63 0.01
43063 BRD-K69556541 HT29 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.85 0.19
43349 BRD-K69556541 MCF??7.00 10 uM 6 h 0.21 0.86 0.01 0.0 0.0 0.0
43630 BRD-K69556541 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43930 BRD-K69556541 PHH 10 uM 24 h -0.27 -1.14 0.42 -0.3 -1.0 0.54
44187 BRD-K69556541 SKB 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
99398 BRD-K69556541 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.69 0.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).