CMap Candidate Details

Structure:
CMap ID: C24579
Pert ID: BRD-K69688083
Compound Name: mestinon
Targets: ACHE
MoA: Cholinesterase inhibitor
SMILES: CN(C)C(=O)Oc1ccc[n+](C)c1
InchiKey: RVOLLAQWKVFTGE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
50042 BRD-K69688083 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50397 BRD-K69688083 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
121735 BRD-K69688083 HA1E 10 uM 24 h 0.29 1.21 0.46 -0.31 -1.05 0.7
121764 BRD-K69688083 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121795 BRD-K69688083 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121843 BRD-K69688083 PC3 10 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
121869 BRD-K69688083 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129757 BRD-K69688083 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129829 BRD-K69688083 HEK293 2.22 uM 24 h -0.27 -1.12 0.39 -0.35 -1.16 1.11
129917 BRD-K69688083 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.53
129956 BRD-K69688083 MCF10A 0.74 uM 24 h 0.3 1.24 0.53 0.36 1.27 1.34
130000 BRD-K69688083 MCF??7.00 0.25 uM 24 h -0.28 -1.15 0.43 0.0 0.0 0.0
130040 BRD-K69688083 MDAMB231 2.22 uM 24 h -0.24 -1.0 0.15 -0.28 -0.96 0.43
130112 BRD-K69688083 THP1 2.22 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).