CMap Candidate Details

Structure:
CMap ID: C02458
Pert ID: BRD-K00206590
Compound Name: P-1075
Targets: KCNJ11
MoA: ATP channel activator; Potassium channel activator
SMILES: CCC(C)(C)N=C(NC#N)Nc1cccnc1
InchiKey: HKZNADVVGXKQDL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4034 BRD-K00206590 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4534 BRD-K00206590 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.19 -0.65 0.01
4764 BRD-K00206590 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5014 BRD-K00206590 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44273 BRD-K00206590 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44502 BRD-K00206590 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44804 BRD-K00206590 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45393 BRD-K00206590 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45629 BRD-K00206590 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
45923 BRD-K00206590 NPC 10 uM 24 h 0.23 0.96 0.08 0.0 0.0 0.0
46241 BRD-K00206590 PHH 10 uM 24 h 0.29 1.19 0.41 0.0 0.0 0.0
46555 BRD-K00206590 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99946 BRD-K00206590 U2OS 10 uM 6 h -0.24 -1.0 0.15 -0.22 -0.75 0.06
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).