CMap Candidate Details

Structure:
CMap ID: C24580
Pert ID: BRD-K69690935
Compound Name: curcumin
Targets: PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor; Lipoxygenase inhibitor; NFKB pathway inhibitor; Histone acetyltransferase inhibitor
SMILES: COc1ccc(C=CC(=O)CC(=O)C=Cc2cccc(O)c2OC)cc1O
InchiKey: VZMSCIKIANDZNI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8973 BRD-K69690935 A375 12.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9114 BRD-K69690935 A549 12.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9489 BRD-K69690935 AGS 12.5 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.36
9945 BRD-K69690935 HA1E 12.5 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
10200 BRD-K69690935 HCC515 12.5 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
10575 BRD-K69690935 HCT116 12.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10832 BRD-K69690935 HEPG2 12.5 uM 6 h -0.23 -0.97 0.1 0.0 0.0 0.0
11094 BRD-K69690935 HT29 12.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11203 BRD-K69690935 MCF??7.00 12.5 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
11819 BRD-K69690935 NCIH508 12.5 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.42
12111 BRD-K69690935 NCIH596 12.5 uM 6 h 0.0 0.0 0.0 -0.24 -0.81 0.13
12520 BRD-K69690935 PC3 12.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
13044 BRD-K69690935 THP1 12.5 uM 6 h 0.29 1.19 0.42 0.0 0.0 0.0
13339 BRD-K69690935 U937 12.5 uM 6 h -0.23 -0.96 0.09 0.27 0.96 0.34
13667 BRD-K69690935 VCAP 12.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).