CMap Candidate Details

Structure:
CMap ID: C24598
Pert ID: BRD-K69726342
Compound Name: atorvastatin
Targets: DPP4; HMGCR
MoA: HMGCR inhibitor
SMILES: CC(C)c1c(C(=O)Nc2ccccc2)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(O)=O)-c1ccccc1
InchiKey: XUKUURHRXDUEBC-KAYWLYCHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
98553 BRD-K69726342 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
98624 BRD-K69726342 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126673 BRD-K69726342 HA1E 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
126691 BRD-K69726342 HEK293 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
126715 BRD-K69726342 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126774 BRD-K69726342 JURKAT 10 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
126836 BRD-K69726342 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
126882 BRD-K69726342 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126946 BRD-K69726342 THP1 10 uM 24 h -0.24 -0.99 0.13 -0.3 -1.0 0.54
134674 BRD-K69726342 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134697 BRD-K69726342 A549 2.22 uM 24 h -0.23 -0.94 0.08 0.34 1.19 1.06
134823 BRD-K69726342 HT29 0.03 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.59
134861 BRD-K69726342 HUVEC 2.22 uM 24 h -0.29 -1.22 0.61 0.0 0.0 0.0
134924 BRD-K69726342 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.37 1.32 1.6
134961 BRD-K69726342 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.86
134989 BRD-K69726342 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).