CMap Candidate Details

Structure:
CMap ID: C24608
Pert ID: BRD-K69763916
Compound Name: LY-341495
Targets: GRM2; GRM3
MoA: Glutamate receptor antagonist
SMILES: N[C@@](CC1c2ccccc2Oc3ccccc13)([C@H]4C[C@@H]4C(=O)O)C(=O)O
InchiKey: VLZBRVJVCCNPRJ-KPHUOKFYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4239 BRD-K69763916 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4470 BRD-K69763916 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.3 1.57
4710 BRD-K69763916 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5114 BRD-K69763916 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44432 BRD-K69763916 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44723 BRD-K69763916 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45009 BRD-K69763916 ASC 10 uM 24 h 0.21 0.89 0.02 0.27 0.95 0.31
45301 BRD-K69763916 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45563 BRD-K69763916 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45842 BRD-K69763916 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.21 1.24
46123 BRD-K69763916 NPC 10 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.05
46437 BRD-K69763916 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46762 BRD-K69763916 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99400 BRD-K69763916 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).