CMap Candidate Details

Structure:
CMap ID: C24657
Pert ID: BRD-K69932463
Compound Name: AZD-8055
Targets: MTOR
MoA: MTOR inhibitor
SMILES: COc1ccc(cc1CO)-c1ccc2c(nc(nc2n1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C
InchiKey: KVLFRAWTRWDEDF-IRXDYDNUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1362 BRD-K69932463 U2OS 10 uM 48 h 0.0 0.0 0.0 -0.35 -1.17 1.11
1434 BRD-K69932463 NPC 0.3 uM 24 h 0.0 0.0 0.0 -0.19 -0.63 0.01
9023 BRD-K69932463 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9491 BRD-K69932463 AGS 10 uM 6 h 0.0 0.0 0.0 0.29 1.02 0.48
9795 BRD-K69932463 H1299 10 uM 6 h 0.0 0.0 0.0 0.27 0.97 0.35
10075 BRD-K69932463 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10257 BRD-K69932463 HCC515 10 uM 6 h -0.21 -0.88 0.03 0.0 0.0 0.0
10834 BRD-K69932463 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11007 BRD-K69932463 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11556 BRD-K69932463 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11821 BRD-K69932463 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12113 BRD-K69932463 NCIH596 10 uM 6 h -0.29 -1.2 0.57 0.21 0.74 0.04
12623 BRD-K69932463 PC3 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.92 0.33
12852 BRD-K69932463 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13341 BRD-K69932463 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13498 BRD-K69932463 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91551 BRD-K69932463 BT20 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91712 BRD-K69932463 MDAMB231 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92424 BRD-K69932463 A549 0.12 uM 24 h -0.24 -0.98 0.12 -0.26 -0.87 0.24
92519 BRD-K69932463 HME1 1.11 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
92598 BRD-K69932463 HS578T 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92647 BRD-K69932463 LNCAP 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
92719 BRD-K69932463 MCF10A 1.11 uM 3 h -0.31 -1.29 0.79 0.24 0.86 0.15
92756 BRD-K69932463 MCF??7.00 10 uM 3 h 0.22 0.93 0.05 -0.41 -1.39 2.02
92843 BRD-K69932463 SKBR3 1.11 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
96035 BRD-K69932463 PHH 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).