CMap Candidate Details

Structure:
CMap ID: C02476
Pert ID: BRD-K00259736
Compound Name: colchicine
Targets: TUBB; TUBB1
MoA: Microtubule inhibitor
SMILES: COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
InchiKey: IAKHMKGGTNLKSZ-INIZCTEOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
99947 BRD-K00259736 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.28 1.45
122873 BRD-K00259736 HEK293 1.11 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
122927 BRD-K00259736 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122998 BRD-K00259736 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123087 BRD-K00259736 MDAMB231 1.11 uM 24 h 0.26 1.1 0.24 -0.29 -0.97 0.45
123159 BRD-K00259736 THP1 10 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
131196 BRD-K00259736 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131225 BRD-K00259736 A549 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131268 BRD-K00259736 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
131320 BRD-K00259736 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131335 BRD-K00259736 HUVEC 0.08 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
131388 BRD-K00259736 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131422 BRD-K00259736 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131451 BRD-K00259736 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
131479 BRD-K00259736 YAPC 0.25 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).