CMap Candidate Details

Structure:
CMap ID: C24774
Pert ID: BRD-K70358946
Compound Name: aripiprazole
Targets: DRD2; HRH1; HTR1A; HTR1B; HTR1D; HTR2A; HTR2C
MoA: Serotonin receptor agonist; Serotonin receptor antagonist
SMILES: Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
InchiKey: CEUORZQYGODEFX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1456 BRD-K70358946 NPC 25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25529 BRD-K70358946 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
52189 BRD-K70358946 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91136 BRD-K70358946 HUH7 8 uM 72 h 0.0 0.0 0.0 0.3 1.05 0.57
126360 BRD-K70358946 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126377 BRD-K70358946 A549 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
126429 BRD-K70358946 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126471 BRD-K70358946 HELA 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
126517 BRD-K70358946 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126551 BRD-K70358946 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126576 BRD-K70358946 PC3 10 uM 24 h 0.3 1.23 0.5 0.24 0.83 0.12
126596 BRD-K70358946 YAPC 10 uM 24 h -0.25 -1.06 0.25 0.0 0.0 0.0
134395 BRD-K70358946 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134458 BRD-K70358946 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134495 BRD-K70358946 HUVEC 0.74 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).