CMap Candidate Details

Structure:
CMap ID: C24797
Pert ID: BRD-K70463136
Compound Name: BAY-87-2243
Targets: HIF1A
MoA: HIF inhibitor
SMILES: Cc1cc(nn1Cc1ccnc(c1)N1CCN(CC1)C1CC1)-c1nc(no1)-c1ccc(OC(F)(F)F)cc1
InchiKey: CDJNNOJINJAXPV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126433 BRD-K70463136 HEK293 0.125 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
126537 BRD-K70463136 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126599 BRD-K70463136 YAPC 10 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
134345 BRD-K70463136 A375 0.25 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
134373 BRD-K70463136 A549 0.03 uM 24 h 0.0 0.0 0.0 -0.43 -1.44 15.35
134398 BRD-K70463136 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134425 BRD-K70463136 HELA 0.25 uM 24 h 0.18 0.76 0.0 -0.25 -0.83 0.17
134460 BRD-K70463136 HT29 0.25 uM 24 h 0.3 1.27 0.58 -0.38 -1.29 1.53
134499 BRD-K70463136 HUVEC 0.01 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
134536 BRD-K70463136 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.02
134595 BRD-K70463136 MDAMB231 2.22 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
134623 BRD-K70463136 PC3 0.25 uM 24 h 0.19 0.78 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).