CMap Candidate Details

Structure:
CMap ID: C24798
Pert ID: BRD-K70464547
Compound Name: sertraline
Targets: SLC6A4
MoA: Serotonin receptor antagonist
SMILES: CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12
InchiKey: VGKDLMBJGBXTGI-YVEFUNNKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126651 BRD-K70464547 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126692 BRD-K70464547 HEK293 10 uM 24 h 0.0 0.0 0.0 0.3 1.04 0.56
126717 BRD-K70464547 HELA 10 uM 24 h 0.25 1.05 0.16 0.49 1.72 2.56
126742 BRD-K70464547 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126777 BRD-K70464547 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126803 BRD-K70464547 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.26
126839 BRD-K70464547 MCF??7.00 10 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
126885 BRD-K70464547 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126913 BRD-K70464547 PC3 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.46
126950 BRD-K70464547 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126995 BRD-K70464547 YAPC 10 uM 24 h 0.0 0.0 0.0 0.42 1.49 2.25
134677 BRD-K70464547 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134729 BRD-K70464547 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
134865 BRD-K70464547 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).