CMap Candidate Details

Structure:
CMap ID: C24812
Pert ID: BRD-K70507123
Compound Name: doxofylline
Targets: ADORA1; PDE4A; PDE4B; PDE4C; PDE4D
MoA: Adenosine receptor antagonist
SMILES: Cn1c2ncn(CC3OCCO3)c2c(=O)n(C)c1=O
InchiKey: HWXIGFIVGWUZAO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91267 BRD-K70507123 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
126695 BRD-K70507123 HEK293 0.125 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.4
126720 BRD-K70507123 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126782 BRD-K70507123 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.2
126805 BRD-K70507123 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
126843 BRD-K70507123 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126888 BRD-K70507123 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.26
126955 BRD-K70507123 THP1 0.125 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
126997 BRD-K70507123 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134680 BRD-K70507123 A375 0.03 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
134702 BRD-K70507123 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134730 BRD-K70507123 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134827 BRD-K70507123 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134869 BRD-K70507123 HUVEC 0.25 uM 24 h 0.26 1.07 0.2 0.35 1.24 1.28
134966 BRD-K70507123 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).