CMap Candidate Details

Structure:
CMap ID: C24814
Pert ID: BRD-K70511574
Compound Name: HMN-214
Targets: CSF1R; FLT1; FLT3; FLT4; KDR; KIT; PDGFRB; RET
MoA: PLK inhibitor
SMILES: COc1ccc(cc1)S(=O)(=O)N(C(C)=O)c1ccccc1C=Cc1cc[n+]([O-])cc1
InchiKey: OCKHRKSTDPOHEN-BQYQJAHWSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3 BRD-K70511574 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
11 BRD-K70511574 NCIH2073 10 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.51
19 BRD-K70511574 NCIH508 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28 BRD-K70511574 NCIH596 10 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
34 BRD-K70511574 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
36330 BRD-K70511574 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36627 BRD-K70511574 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36858 BRD-K70511574 VCAP 10 uM 24 h 0.0 0.0 0.0 0.38 1.36 1.72
91825 BRD-K70511574 HS578T 10 uM 6 h 0.0 0.0 0.0 0.21 0.76 0.05
91881 BRD-K70511574 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
94418 BRD-K70511574 A375 0.12 uM 24 h 0.28 1.19 0.41 -0.22 -0.76 0.07
94489 BRD-K70511574 ASC 0.04 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.58
94558 BRD-K70511574 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94604 BRD-K70511574 HCC515 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94753 BRD-K70511574 HME1 10 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
94796 BRD-K70511574 HT29 3.33 uM 24 h -0.27 -1.12 0.39 -0.3 -1.0 0.54
94845 BRD-K70511574 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94942 BRD-K70511574 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95023 BRD-K70511574 NEU 0.37 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
95091 BRD-K70511574 NPC 0.12 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
95121 BRD-K70511574 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
95171 BRD-K70511574 SHSY5Y 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95214 BRD-K70511574 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95395 BRD-K70511574 U2OS 10 uM 24 h -0.19 -0.8 0.0 -0.38 -1.27 1.43
126674 BRD-K70511574 HA1E 3.33 uM 24 h -0.28 -1.16 0.46 -0.34 -1.13 0.99
126693 BRD-K70511574 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.37 2.02
126779 BRD-K70511574 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
126952 BRD-K70511574 THP1 3.33 uM 24 h 0.19 0.78 0.0 -0.22 -0.75 0.06
134700 BRD-K70511574 A549 2.22 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.83
134798 BRD-K70511574 HELA 2.22 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.71
134942 BRD-K70511574 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.81
134991 BRD-K70511574 YAPC 0.74 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.22
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).