CMap Candidate Details

Structure:
CMap ID: C24825
Pert ID: BRD-K70549064
Compound Name: staurosporine
Targets: CDK2; GSK3B
MoA: PKC inhibitor
SMILES: CN[C@@H]1C[C@@]2(C)O[C@@H]([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
InchiKey: XTGJCWHCHWNXSE-WQGXBGQBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33674 BRD-K70549064 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33923 BRD-K70549064 A549 10 uM 6 h 0.0 0.0 0.0 0.23 0.83 0.11
34163 BRD-K70549064 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34409 BRD-K70549064 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34669 BRD-K70549064 HCC515 10 uM 6 h 0.0 0.0 0.0 0.25 0.88 0.18
34943 BRD-K70549064 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35189 BRD-K70549064 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35339 BRD-K70549064 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35991 BRD-K70549064 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36331 BRD-K70549064 PHH 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
36628 BRD-K70549064 SKB 10 uM 24 h 0.25 1.04 0.14 -0.24 -0.79 0.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).