CMap Candidate Details
Structure:
| CMap ID: | C24837 |
| Pert ID: | BRD-K70578146 |
| Compound Name: | dactinomycin |
| Targets: | POLR2A |
| MoA: | RNA polymerase inhibitor |
| SMILES: | CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O |
| InchiKey: | RJURFGZVJUQBHK-IIXSONLDSA-N |
| Compound Aliases: | -- |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 22091 | BRD-K70578146 | A375 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.31 | 1.11 | 0.71 |
| 22155 | BRD-K70578146 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.29 | -0.98 | 0.48 |
| 22549 | BRD-K70578146 | HA1E | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.28 | 0.99 | 0.39 |
| 22832 | BRD-K70578146 | HCC515 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.33 | 1.16 | 0.9 |
| 23130 | BRD-K70578146 | HEPG2 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 23420 | BRD-K70578146 | HT29 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.34 | 1.19 | 1.02 |
| 23623 | BRD-K70578146 | MCF??7.00 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 24028 | BRD-K70578146 | PC3 | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.24 | 0.84 | 0.13 |
| 24341 | BRD-K70578146 | VCAP | 10 uM | 6 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |