CMap Candidate Details

Structure:
CMap ID: C24856
Pert ID: BRD-K70642949
Compound Name: GSK-2334470
Targets: PDK1; PDPK1
MoA: Pyruvate dehydrogenase kinase inhibitor
SMILES: CNc1nc(cc(n1)-c1ccc2c(N)n[nH]c2c1)N1C[C@H](CC[C@H]1C)C(=O)NC1CCCCC1
InchiKey: QLPHOXTXAKOFMU-WBVHZDCISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9796 BRD-K70642949 H1299 0.12 uM 6 h 0.0 0.0 0.0 0.21 0.73 0.03
9976 BRD-K70642949 HA1E 0.12 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.98
10577 BRD-K70642949 HCT116 0.12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10835 BRD-K70642949 HEPG2 0.12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11557 BRD-K70642949 NCIH2073 0.12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11822 BRD-K70642949 NCIH508 0.12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12114 BRD-K70642949 NCIH596 0.12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12372 BRD-K70642949 NOMO1 0.12 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.47
12853 BRD-K70642949 SW480 0.12 uM 6 h 0.19 0.81 0.0 0.31 1.1 0.68
13342 BRD-K70642949 U937 0.12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13668 BRD-K70642949 VCAP 0.12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
94421 BRD-K70642949 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94455 BRD-K70642949 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94515 BRD-K70642949 ASC 10 uM 24 h 0.25 1.05 0.17 -0.29 -0.97 0.47
94561 BRD-K70642949 CD34 10 uM 24 h 0.26 1.1 0.24 -0.36 -1.22 1.24
94607 BRD-K70642949 HCC515 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94650 BRD-K70642949 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94699 BRD-K70642949 HELA 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
94756 BRD-K70642949 HME1 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.21
94798 BRD-K70642949 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94848 BRD-K70642949 HUVEC 0.04 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
94899 BRD-K70642949 JURKAT 10 uM 24 h -0.3 -1.24 0.67 0.0 0.0 0.0
94945 BRD-K70642949 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94982 BRD-K70642949 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95026 BRD-K70642949 NEU 10 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
95056 BRD-K70642949 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95124 BRD-K70642949 PC3 10 uM 24 h -0.22 -0.9 0.05 0.18 0.64 0.0
95174 BRD-K70642949 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95241 BRD-K70642949 SKL 10 uM 24 h 0.0 0.0 0.0 -0.45 -1.51 15.35
95283 BRD-K70642949 THP1 10 uM 24 h -0.26 -1.1 0.34 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).