CMap Candidate Details

Structure:
CMap ID: C24876
Pert ID: BRD-K70693222
Compound Name: BRD-K70693222
Targets: CLK1; DYRK1A; CLK4
MoA: DYRK inhibitor
SMILES: C(Nc1ncnc2ccc(cc12)c3ccc4OCOc4c3)c5cccs5
InchiKey: QFBOPHGXTBOQRN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
14314 BRD-K70693222 A549 10 uM 6 h 0.0 0.0 0.0 0.22 0.77 0.05
14660 BRD-K70693222 HA1E 10 uM 6 h -0.2 -0.83 0.0 0.29 1.03 0.5
15517 BRD-K70693222 MCF??7.00 10 uM 6 h 0.21 0.89 0.02 0.27 0.95 0.32
16485 BRD-K70693222 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
17083 BRD-K70693222 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
17418 BRD-K70693222 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
17761 BRD-K70693222 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
18321 BRD-K70693222 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
18616 BRD-K70693222 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115163 BRD-K70693222 U2OS 20 uM 6 h 0.26 1.09 0.22 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).