CMap Candidate Details

Structure:
CMap ID: C02489
Pert ID: BRD-K00313977
Compound Name: BRD-K00313977
Targets: APEX1
MoA: APEX inhibitor
SMILES: CC(C)N1Cc2sc(NC(C)=O)c(-c3nc4ccccc4s3)c2C1
InchiKey: CZIACNCULOWAAI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
18925 BRD-K00313977 A375 10 uM 6 h -0.26 -1.07 0.27 -0.35 -1.16 1.11
19401 BRD-K00313977 A549 10 uM 6 h -0.17 -0.73 0.0 -0.38 -1.27 1.39
19575 BRD-K00313977 HA1E 10 uM 6 h -0.21 -0.86 0.02 -0.29 -0.97 0.46
19898 BRD-K00313977 HCC515 10 uM 6 h -0.29 -1.2 0.55 0.2 0.73 0.03
20227 BRD-K00313977 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.39 -1.3 1.58
20557 BRD-K00313977 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
20849 BRD-K00313977 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
21384 BRD-K00313977 PC3 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.11 0.91
21508 BRD-K00313977 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).