CMap Candidate Details

Structure:
CMap ID: C24899
Pert ID: BRD-K70778732
Compound Name: trazodone
Targets: HTR2A; HTR2C; SLC6A4
MoA: Serotonin reuptake inhibitor; Serotonin receptor antagonist; Adrenergic receptor antagonist
SMILES: Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1
InchiKey: PHLBKPHSAVXXEF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5678 BRD-K70778732 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5950 BRD-K70778732 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25530 BRD-K70778732 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.92 0.33
39753 BRD-K70778732 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40856 BRD-K70778732 NEU 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.16
41171 BRD-K70778732 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41509 BRD-K70778732 SKB 10 uM 24 h -0.24 -0.99 0.13 0.0 0.0 0.0
99407 BRD-K70778732 U2OS 10 uM 6 h 0.0 0.0 0.0 0.34 1.19 1.01
126378 BRD-K70778732 A549 0.37 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
126431 BRD-K70778732 HEK293 0.04 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
126473 BRD-K70778732 HELA 1.11 uM 24 h -0.25 -1.05 0.23 0.22 0.78 0.06
126519 BRD-K70778732 MCF10A 3.33 uM 24 h -0.24 -0.99 0.13 -0.25 -0.83 0.17
126535 BRD-K70778732 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126553 BRD-K70778732 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134343 BRD-K70778732 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134396 BRD-K70778732 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134459 BRD-K70778732 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.71
134497 BRD-K70778732 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.65
134621 BRD-K70778732 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134650 BRD-K70778732 YAPC 0.25 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).