CMap Candidate Details

Structure:
CMap ID: C24905
Pert ID: BRD-K70799801
Compound Name: quinidine
Targets: SCN5A
MoA: Sodium channel blocker
SMILES: COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
InchiKey: LOUPRKONTZGTKE-LHHVKLHASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4243 BRD-K70799801 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4474 BRD-K70799801 HCC515 10 uM 24 h -0.21 -0.89 0.04 -0.32 -1.08 0.81
4818 BRD-K70799801 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5118 BRD-K70799801 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.92 0.31
39168 BRD-K70799801 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39482 BRD-K70799801 A549 10 uM 6 h -0.2 -0.84 0.0 0.0 0.0 0.0
39754 BRD-K70799801 ASC 10 uM 24 h 0.31 1.28 0.61 0.0 0.0 0.0
40047 BRD-K70799801 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40314 BRD-K70799801 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40499 BRD-K70799801 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40857 BRD-K70799801 NEU 10 uM 24 h -0.23 -0.96 0.1 -0.22 -0.72 0.04
41172 BRD-K70799801 NPC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.72
41510 BRD-K70799801 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99409 BRD-K70799801 U2OS 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).