CMap Candidate Details

Structure:
CMap ID: C24955
Pert ID: BRD-K70924353
Compound Name: amtolmetin-guacil
Targets: PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor
SMILES: COc1ccccc1OC(=O)CNC(=O)Cc1ccc(C(=O)c2ccc(C)cc2)n1C
InchiKey: CWJNMKKMGIAGDK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126697 BRD-K70924353 HEK293 0.37 uM 24 h -0.22 -0.93 0.07 -0.18 -0.62 0.0
126722 BRD-K70924353 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126806 BRD-K70924353 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126845 BRD-K70924353 MCF??7.00 10 uM 24 h 0.2 0.84 0.0 0.0 0.0 0.0
126890 BRD-K70924353 MDAMB231 0.125 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
126957 BRD-K70924353 THP1 1.11 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
126998 BRD-K70924353 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.22 0.76 0.05
134682 BRD-K70924353 A375 0.25 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
134704 BRD-K70924353 A549 0.03 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.42
134732 BRD-K70924353 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
134829 BRD-K70924353 HT29 2.22 uM 24 h -0.25 -1.03 0.19 0.0 0.0 0.0
134871 BRD-K70924353 HUVEC 0.08 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
134900 BRD-K70924353 JURKAT 2.22 uM 24 h -0.19 -0.81 0.0 0.24 0.84 0.13
134968 BRD-K70924353 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).