CMap Candidate Details

Structure:
CMap ID: C00025
Pert ID: BRD-A00938334
Compound Name: drospirenone
Targets: NR3C2; PGR
MoA: Mineralocorticoid receptor antagonist
SMILES: C[C@]12CCC3C([C@H]4C[C@H]4C4=CC(=O)CC[C@]34C)C1[C@@H]1C[C@@H]1[C@@]21CCC(=O)O1
InchiKey: METQSPRSQINEEU-GGORKCOASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122856 BRD-A00938334 HA1E 10 uM 24 h 0.25 1.03 0.13 0.29 1.04 0.55
122885 BRD-A00938334 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.59
122935 BRD-A00938334 HELA 10 uM 24 h 0.28 1.18 0.39 -0.3 -0.99 0.51
123010 BRD-A00938334 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123057 BRD-A00938334 MCF10A 1.11 uM 24 h 0.28 1.15 0.34 0.36 1.26 1.29
123099 BRD-A00938334 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123171 BRD-A00938334 THP1 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123214 BRD-A00938334 YAPC 0.37 uM 24 h -0.36 -1.51 1.43 0.0 0.0 0.0
131204 BRD-A00938334 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131236 BRD-A00938334 A549 0.01 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
131324 BRD-A00938334 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131347 BRD-A00938334 HUVEC 0.25 uM 24 h 0.23 0.97 0.08 0.29 1.04 0.53
131429 BRD-A00938334 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
131457 BRD-A00938334 PC3 0.08 uM 24 h 0.26 1.09 0.23 -0.22 -0.74 0.06
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).