CMap Candidate Details

Structure:
CMap ID: C25001
Pert ID: BRD-K71075609
Compound Name: dorzolamide
Targets: CA1; CA2
MoA: Carbonic anhydrase inhibitor
SMILES: CCN[C@@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
InchiKey: IAVUPMFITXYVAF-POYBYMJQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126631 BRD-K71075609 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126723 BRD-K71075609 HELA 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126745 BRD-K71075609 HT29 10 uM 24 h 0.22 0.93 0.05 0.2 0.69 0.01
126784 BRD-K71075609 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126846 BRD-K71075609 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126916 BRD-K71075609 PC3 10 uM 24 h 0.24 1.02 0.13 -0.22 -0.75 0.06
126958 BRD-K71075609 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.6
134705 BRD-K71075609 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134733 BRD-K71075609 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
134768 BRD-K71075609 HEK293 0.74 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.93
134872 BRD-K71075609 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.12
134930 BRD-K71075609 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
134944 BRD-K71075609 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
134994 BRD-K71075609 YAPC 0.74 uM 24 h 0.2 0.84 0.0 -0.3 -0.99 0.51
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).