CMap Candidate Details

Structure:
CMap ID: C25010
Pert ID: BRD-K71106091
Compound Name: fludarabine-phosphate
Targets: POLA1; RRM1
MoA: Purine antagonist; DNA synthesis inhibitor; DNA repair enzyme inhibitor
SMILES: Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
InchiKey: GIUYCYHIANZCFB-FJFJXFQQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
117336 BRD-K71106091 A375 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
117458 BRD-K71106091 HCC515 10 uM 24 h 0.27 1.11 0.26 0.0 0.0 0.0
117505 BRD-K71106091 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126724 BRD-K71106091 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126807 BRD-K71106091 MCF10A 10 uM 24 h -0.22 -0.9 0.04 0.0 0.0 0.0
126847 BRD-K71106091 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
126891 BRD-K71106091 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.17 0.6 0.0
126917 BRD-K71106091 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126959 BRD-K71106091 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134706 BRD-K71106091 A549 2.22 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
134734 BRD-K71106091 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134769 BRD-K71106091 HEK293 2.22 uM 24 h 0.27 1.13 0.29 0.0 0.0 0.0
134830 BRD-K71106091 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134873 BRD-K71106091 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134901 BRD-K71106091 JURKAT 2.22 uM 24 h 0.26 1.07 0.2 0.25 0.87 0.18
134995 BRD-K71106091 YAPC 0.25 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).