CMap Candidate Details

Structure:
CMap ID: C25051
Pert ID: BRD-K71221037
Compound Name: birinapant
Targets: BIRC2; XIAP
MoA: XIAP inhibitor
SMILES: CC[C@H](NC(=O)[C@H](C)NC)C(=O)N1C[C@@H](O)C[C@H]1Cc1c([nH]c2cc(F)ccc12)-c1[nH]c2cc(F)ccc2c1C[C@@H]1C[C@H](O)CN1C(=O)[C@H](CC)NC(=O)[C@H](C)NC
InchiKey: PKWRMUKBEYJEIX-DXXQBUJASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1145 BRD-K71221037 A549 0.12 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.91
1179 BRD-K71221037 PC3 1.11 uM 24 h 0.2 0.82 0.0 -0.23 -0.79 0.1
1283 BRD-K71221037 MCF??7.00 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1382 BRD-K71221037 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.61
126402 BRD-K71221037 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.44
126436 BRD-K71221037 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126476 BRD-K71221037 HELA 0.04 uM 24 h 0.23 0.96 0.08 0.0 0.0 0.0
126602 BRD-K71221037 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134347 BRD-K71221037 A375 0.03 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.36
134462 BRD-K71221037 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134502 BRD-K71221037 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
134538 BRD-K71221037 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134597 BRD-K71221037 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 -0.39 -1.33 1.71
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).