CMap Candidate Details

Structure:
CMap ID: C25074
Pert ID: BRD-K71289571
Compound Name: zafirlukast
Targets: CYSLTR1
MoA: Leukotriene receptor antagonist
SMILES: COc1cc(ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
InchiKey: YEEZWCHGZNKEEK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25532 BRD-K71289571 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50400 BRD-K71289571 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.29
51626 BRD-K71289571 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
91072 BRD-K71289571 HUH7 6.66 uM 72 h -0.27 -1.12 0.38 0.0 0.0 0.0
126364 BRD-K71289571 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126405 BRD-K71289571 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126441 BRD-K71289571 HEK293 10 uM 24 h 0.26 1.06 0.19 0.0 0.0 0.0
126496 BRD-K71289571 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126605 BRD-K71289571 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134377 BRD-K71289571 A549 0.01 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
134430 BRD-K71289571 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.33 1.16 0.9
134507 BRD-K71289571 HUVEC 0.08 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.52
134541 BRD-K71289571 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
134600 BRD-K71289571 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.2 0.71 0.02
134628 BRD-K71289571 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.32 1.13 0.84
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).