CMap Candidate Details

Structure:
CMap ID: C25129
Pert ID: BRD-K71480163
Compound Name: GDC-0068
Targets: AKT3; AKT1; AKT2
MoA: Akt inhibitor
SMILES: CC(C)NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2[C@@H](O)C[C@@H](C)c12)c1ccc(Cl)cc1
InchiKey: GRZXWCHAXNAUHY-AHRSYUTCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90814 BRD-K71480163 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
95612 BRD-K71480163 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95649 BRD-K71480163 U2OS 10 uM 24 h -0.22 -0.9 0.05 -0.4 -1.33 1.84
126403 BRD-K71480163 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126438 BRD-K71480163 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126477 BRD-K71480163 HELA 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
126555 BRD-K71480163 MDAMB231 3.33 uM 24 h -0.2 -0.83 0.0 0.27 0.95 0.31
134348 BRD-K71480163 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134376 BRD-K71480163 A549 2.22 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.96
134463 BRD-K71480163 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134504 BRD-K71480163 HUVEC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134626 BRD-K71480163 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.62
134651 BRD-K71480163 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).