CMap Candidate Details

Structure:
CMap ID: C25184
Pert ID: BRD-K71603915
Compound Name: EVP-6124
Targets: CHRNA7
MoA: Acetylcholine receptor agonist
SMILES: Clc1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
InchiKey: SSRDSYXGYPJKRR-ZDUSSCGKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96297 BRD-K71603915 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96369 BRD-K71603915 PC3 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
126656 BRD-K71603915 A549 10 uM 24 h 0.2 0.85 0.01 0.0 0.0 0.0
126810 BRD-K71603915 MCF10A 10 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
126852 BRD-K71603915 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126896 BRD-K71603915 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126964 BRD-K71603915 THP1 3.33 uM 24 h -0.28 -1.17 0.5 0.26 0.94 0.28
134738 BRD-K71603915 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
134773 BRD-K71603915 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
134802 BRD-K71603915 HELA 0.74 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
134832 BRD-K71603915 HT29 2.22 uM 24 h -0.25 -1.05 0.22 0.0 0.0 0.0
134878 BRD-K71603915 HUVEC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134904 BRD-K71603915 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
134997 BRD-K71603915 YAPC 2.22 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).