CMap Candidate Details

Structure:
CMap ID: C25215
Pert ID: BRD-K71726959
Compound Name: BRD-K71726959
Targets: CDK5; CDK1
MoA: CDK inhibitor
SMILES: CC(C)n1cnc2c(NCc3ccccc3)nc(NCCO)nc12
InchiKey: WHDJEAZLMYPLGL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8975 BRD-K71726959 A375 125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9493 BRD-K71726959 AGS 125 uM 6 h -0.19 -0.81 0.0 0.31 1.1 0.69
9798 BRD-K71726959 H1299 125 uM 6 h 0.0 0.0 0.0 0.26 0.94 0.28
9908 BRD-K71726959 HA1E 125 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
10152 BRD-K71726959 HCC515 125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10579 BRD-K71726959 HCT116 125 uM 6 h 0.0 0.0 0.0 0.37 1.32 1.71
10837 BRD-K71726959 HEPG2 125 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11008 BRD-K71726959 HT29 125 uM 24 h 0.0 0.0 0.0 0.26 0.9 0.23
11292 BRD-K71726959 MCF??7.00 125 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11559 BRD-K71726959 NCIH2073 125 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11824 BRD-K71726959 NCIH508 125 uM 6 h -0.27 -1.14 0.42 0.0 0.0 0.0
12116 BRD-K71726959 NCIH596 125 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12373 BRD-K71726959 NOMO1 125 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12476 BRD-K71726959 PC3 125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12855 BRD-K71726959 SW480 125 uM 6 h -0.23 -0.95 0.09 0.0 0.0 0.0
12991 BRD-K71726959 THP1 125 uM 6 h 0.17 0.71 0.0 0.0 0.0 0.0
13343 BRD-K71726959 U937 125 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13670 BRD-K71726959 VCAP 125 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42136 BRD-K71726959 A549 10 uM 6 h 0.0 0.0 0.0 0.31 1.1 0.68
42456 BRD-K71726959 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43634 BRD-K71726959 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43933 BRD-K71726959 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99421 BRD-K71726959 U2OS 15 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).