CMap Candidate Details

Structure:
CMap ID: C25242
Pert ID: BRD-K71799778
Compound Name: BML-259
Targets: CDK2; CDK5
MoA: CDK inhibitor
SMILES: CC(C)c1cnc(NC(=O)Cc2ccccc2)s1
InchiKey: IGRZXNLKVUEFDM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9030 BRD-K71799778 A375 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9226 BRD-K71799778 A549 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9494 BRD-K71799778 AGS 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9799 BRD-K71799778 H1299 80 uM 6 h 0.0 0.0 0.0 0.21 0.76 0.05
9909 BRD-K71799778 HA1E 80 uM 24 h -0.27 -1.1 0.36 -0.23 -0.78 0.1
10287 BRD-K71799778 HCC515 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10580 BRD-K71799778 HCT116 80 uM 6 h -0.16 -0.65 0.0 0.19 0.66 0.01
10838 BRD-K71799778 HEPG2 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11072 BRD-K71799778 HT29 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11293 BRD-K71799778 MCF??7.00 80 uM 6 h 0.0 0.0 0.0 -0.3 -1.03 0.62
11560 BRD-K71799778 NCIH2073 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12624 BRD-K71799778 PC3 80 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.26
12856 BRD-K71799778 SW480 80 uM 6 h 0.2 0.85 0.01 0.2 0.72 0.02
13344 BRD-K71799778 U937 80 uM 6 h -0.22 -0.91 0.05 0.0 0.0 0.0
13671 BRD-K71799778 VCAP 80 uM 6 h -0.26 -1.07 0.28 0.33 1.15 0.9
99423 BRD-K71799778 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).