CMap Candidate Details

Structure:
CMap ID: C25370
Pert ID: BRD-K72222507
Compound Name: quinapril
Targets: ACE
MoA: Angiotensin converting enzyme inhibitor
SMILES: CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(O)=O
InchiKey: JSDRRTOADPPCHY-HSQYWUDLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5681 BRD-K72222507 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6361 BRD-K72222507 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52815 BRD-K72222507 HEPG2 0.66 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
91407 BRD-K72222507 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99429 BRD-K72222507 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.75 0.06
126380 BRD-K72222507 A549 1.11 uM 24 h -0.27 -1.1 0.36 -0.34 -1.15 1.07
126439 BRD-K72222507 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126556 BRD-K72222507 MDAMB231 0.37 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
126578 BRD-K72222507 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.97
134349 BRD-K72222507 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134400 BRD-K72222507 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.38 1.33 1.72
134428 BRD-K72222507 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134464 BRD-K72222507 HT29 0.25 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.35
134505 BRD-K72222507 HUVEC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134540 BRD-K72222507 MCF10A 0.08 uM 24 h 0.23 0.96 0.07 0.0 0.0 0.0
134568 BRD-K72222507 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.37
134652 BRD-K72222507 YAPC 0.25 uM 24 h 0.22 0.94 0.05 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).