CMap Candidate Details

Structure:
CMap ID: C25423
Pert ID: BRD-K72420232
Compound Name: WZ-4002
Targets: EGFR; ERBB2
MoA: EGFR inhibitor
SMILES: COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1
InchiKey: ITTRLTNMFYIYPA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
52 BRD-K72420232 BJAB 10 uM 4 h 0.25 1.05 0.17 0.0 0.0 0.0
87 BRD-K72420232 HBL1 10 uM 24 h 0.24 1.0 0.11 0.4 1.41 2.19
124 BRD-K72420232 K562 10 uM 24 h -0.23 -0.97 0.11 -0.24 -0.82 0.15
174 BRD-K72420232 KMS34 10 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
217 BRD-K72420232 NALM6 10 uM 24 h 0.18 0.74 0.0 -0.21 -0.71 0.03
256 BRD-K72420232 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
310 BRD-K72420232 OCILY19 10 uM 4 h 0.0 0.0 0.0 0.37 1.3 1.49
331 BRD-K72420232 OCILY3 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
373 BRD-K72420232 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.13
421 BRD-K72420232 THP1 10 uM 4 h 0.0 0.0 0.0 0.33 1.16 0.9
461 BRD-K72420232 TMD8 10 uM 4 h 0.0 0.0 0.0 0.22 0.79 0.07
33563 BRD-K72420232 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34671 BRD-K72420232 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34945 BRD-K72420232 HEPG2 10 uM 6 h -0.27 -1.11 0.37 0.32 1.13 0.84
35611 BRD-K72420232 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36335 BRD-K72420232 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36632 BRD-K72420232 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36997 BRD-K72420232 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91522 BRD-K72420232 BT20 10 uM 24 h 0.0 0.0 0.0 0.39 1.39 2.17
91610 BRD-K72420232 HS578T 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91637 BRD-K72420232 MCF10A 10 uM 6 h 0.0 0.0 0.0 0.42 1.5 2.27
91696 BRD-K72420232 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.51
91778 BRD-K72420232 SKBR3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92943 BRD-K72420232 ASC 10 uM 24 h -0.22 -0.91 0.05 -0.2 -0.69 0.02
93011 BRD-K72420232 CD34 10 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.3
93050 BRD-K72420232 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93098 BRD-K72420232 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93139 BRD-K72420232 HELA 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
93237 BRD-K72420232 HUVEC 10 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
93289 BRD-K72420232 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93427 BRD-K72420232 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93456 BRD-K72420232 PC3 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
93495 BRD-K72420232 SKL 10 uM 24 h 0.0 0.0 0.0 0.35 1.23 1.19
93594 BRD-K72420232 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116716 BRD-K72420232 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116896 BRD-K72420232 HT29 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
116938 BRD-K72420232 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).