CMap Candidate Details

Structure:
CMap ID: C25509
Pert ID: BRD-K72703948
Compound Name: ZM-447439
Targets: AURKA; AURKB
MoA: Aurora kinase inhibitor
SMILES: COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1
InchiKey: OGNYUTNQZVRGMN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
476 BRD-K72703948 BJAB 10 uM 24 h -0.23 -0.95 0.08 0.0 0.0 0.0
522 BRD-K72703948 HBL1 10 uM 24 h -0.25 -1.04 0.22 -0.45 -1.51 15.35
566 BRD-K72703948 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
614 BRD-K72703948 KMS34 10 uM 24 h -0.22 -0.9 0.04 -0.3 -1.01 0.56
659 BRD-K72703948 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
706 BRD-K72703948 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
750 BRD-K72703948 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
800 BRD-K72703948 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
847 BRD-K72703948 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
951 BRD-K72703948 TMD8 10 uM 4 h -0.25 -1.03 0.2 -0.32 -1.09 0.82
33125 BRD-K72703948 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36336 BRD-K72703948 PHH 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.15
36862 BRD-K72703948 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91827 BRD-K72703948 HS578T 0.37 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.28
91917 BRD-K72703948 MDAMB231 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91971 BRD-K72703948 SKBR3 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.46
94458 BRD-K72703948 A549 10 uM 24 h -0.27 -1.11 0.36 0.0 0.0 0.0
94518 BRD-K72703948 ASC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94565 BRD-K72703948 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94653 BRD-K72703948 HEK293 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94703 BRD-K72703948 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94760 BRD-K72703948 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94852 BRD-K72703948 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94902 BRD-K72703948 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94948 BRD-K72703948 MCF10A 0.04 uM 24 h -0.23 -0.96 0.09 0.0 0.0 0.0
95030 BRD-K72703948 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95083 BRD-K72703948 NPC 0.37 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.65
95178 BRD-K72703948 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.02
95218 BRD-K72703948 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95287 BRD-K72703948 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99433 BRD-K72703948 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
119187 BRD-K72703948 A375 10 uM 24 h 0.23 0.94 0.06 0.27 0.96 0.33
119243 BRD-K72703948 HA1E 10 uM 24 h -0.21 -0.86 0.01 0.0 0.0 0.0
119275 BRD-K72703948 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119304 BRD-K72703948 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119330 BRD-K72703948 HT29 10 uM 24 h -0.27 -1.14 0.42 -0.2 -0.67 0.02
119353 BRD-K72703948 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
119378 BRD-K72703948 PC3 10 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).