CMap Candidate Details

Structure:
CMap ID: C25557
Pert ID: BRD-K72827473
Compound Name: CEP-37440
Targets: ALK
MoA: ALK inhibitor
SMILES: CNC(=O)c1ccccc1Nc1nc(Nc2ccc3C[C@H](CCCc3c2OC)N2CCN(CCO)CC2)ncc1Cl
InchiKey: BCSHRERPHLTPEE-NRFANRHFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95607 BRD-K72827473 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95637 BRD-K72827473 U2OS 10 uM 24 h 0.0 0.0 0.0 -0.44 -1.49 15.35
126659 BRD-K72827473 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126752 BRD-K72827473 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.21 0.73 0.03
126789 BRD-K72827473 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
126816 BRD-K72827473 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
126921 BRD-K72827473 PC3 10 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
126972 BRD-K72827473 THP1 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
134686 BRD-K72827473 A375 2.22 uM 24 h -0.28 -1.15 0.43 -0.31 -1.04 0.66
134745 BRD-K72827473 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134780 BRD-K72827473 HEK293 0.01 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
134808 BRD-K72827473 HELA 2.22 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
134886 BRD-K72827473 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134946 BRD-K72827473 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135003 BRD-K72827473 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).