CMap Candidate Details

Structure:
CMap ID: C25578
Pert ID: BRD-K72895815
Compound Name: SSR-69071
Targets: ELANE
MoA: Leukocyte elastase inhibitor
SMILES: COc1cc2c(C(=O)N(COc3cc(=O)n4cccc(OCCN5CCCCC5)c4n3)S2(=O)=O)c(c1)C(C)C
InchiKey: DRZXDZYWZSKFDL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4137 BRD-K72895815 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
4478 BRD-K72895815 HCC515 10 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
4820 BRD-K72895815 PC3 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.61
5121 BRD-K72895815 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44437 BRD-K72895815 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44726 BRD-K72895815 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45014 BRD-K72895815 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45307 BRD-K72895815 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45568 BRD-K72895815 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45715 BRD-K72895815 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46129 BRD-K72895815 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46443 BRD-K72895815 PHH 10 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
46768 BRD-K72895815 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99436 BRD-K72895815 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).