CMap Candidate Details

Structure:
CMap ID: C02561
Pert ID: BRD-K00521308
Compound Name: ATN-161
Targets: ITGA5; ITGAV; ITGB1; ITGB3
MoA: Integrin inhibitor
SMILES: CC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O
InchiKey: MMHDBUJXLOFTLC-WOYTXXSLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95718 BRD-K00521308 U2OS 0.12 uM 6 h 0.0 0.0 0.0 -0.16 -0.53 0.0
96658 BRD-K00521308 PC3 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
97275 BRD-K00521308 HAP1 3.33 uM 24 h -0.22 -0.91 0.06 -0.3 -1.02 0.61
97355 BRD-K00521308 A375 0.66 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
122880 BRD-K00521308 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122932 BRD-K00521308 HELA 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.15
123005 BRD-K00521308 JURKAT 0.04 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
123094 BRD-K00521308 MDAMB231 10 uM 24 h 0.17 0.73 0.0 0.0 0.0 0.0
123166 BRD-K00521308 THP1 1.11 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.24
123212 BRD-K00521308 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131231 BRD-K00521308 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131271 BRD-K00521308 HA1E 2.22 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
131321 BRD-K00521308 HT29 0.08 uM 24 h 0.33 1.36 0.97 0.0 0.0 0.0
131342 BRD-K00521308 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131392 BRD-K00521308 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131426 BRD-K00521308 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).