CMap Candidate Details

Structure:
CMap ID: C25679
Pert ID: BRD-K73196317
Compound Name: urapidil
Targets: HTR1A
MoA: Adrenergic receptor antagonist
SMILES: COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1
InchiKey: ICMGLRUYEQNHPF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25415 BRD-K73196317 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52191 BRD-K73196317 MCF??7.00 10 uM 6 h 0.24 1.0 0.11 -0.26 -0.89 0.26
52331 BRD-K73196317 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99442 BRD-K73196317 U2OS 10 uM 6 h -0.23 -0.96 0.1 -0.33 -1.12 0.95
126383 BRD-K73196317 A549 0.125 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
126444 BRD-K73196317 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.12
126479 BRD-K73196317 HELA 0.37 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.26
126607 BRD-K73196317 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134352 BRD-K73196317 A375 2.22 uM 24 h -0.29 -1.19 0.53 0.0 0.0 0.0
134403 BRD-K73196317 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.37 -1.25 1.35
134467 BRD-K73196317 HT29 0.08 uM 24 h 0.2 0.82 0.0 -0.26 -0.89 0.26
134510 BRD-K73196317 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134543 BRD-K73196317 MCF10A 0.03 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
134603 BRD-K73196317 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).