CMap Candidate Details

Structure:
CMap ID: C25696
Pert ID: BRD-K73255294
Compound Name: nutlin-3
Targets: MDM2
MoA: MDM inhibitor
SMILES: COc1ccc(C2=N[C@@H]([C@@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
InchiKey: BDUHCSBCVGXTJM-IZLXSDGUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
118704 BRD-K73255294 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118739 BRD-K73255294 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118777 BRD-K73255294 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118817 BRD-K73255294 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118860 BRD-K73255294 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118902 BRD-K73255294 HT29 3.33 uM 24 h -0.26 -1.07 0.27 0.0 0.0 0.0
118937 BRD-K73255294 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118971 BRD-K73255294 PC3 0.12 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).