CMap Candidate Details

Structure:
CMap ID: C25720
Pert ID: BRD-K73319509
Compound Name: PF-04217903
Targets: MET
MoA: C-Met inhibitor
SMILES: OCCn1cc(cn1)-c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
InchiKey: PDMUGYOXRHVNMO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9496 BRD-K73319509 AGS 40 uM 6 h 0.0 0.0 0.0 -0.34 -1.15 1.07
9800 BRD-K73319509 H1299 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10155 BRD-K73319509 HCC515 40 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11826 BRD-K73319509 NCIH508 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12119 BRD-K73319509 NCIH596 40 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13347 BRD-K73319509 U937 40 uM 6 h -0.21 -0.88 0.03 0.0 0.0 0.0
13499 BRD-K73319509 VCAP 40 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
91828 BRD-K73319509 HS578T 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91948 BRD-K73319509 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92925 BRD-K73319509 ASC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92987 BRD-K73319509 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93075 BRD-K73319509 HEK293 0.12 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
93164 BRD-K73319509 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93269 BRD-K73319509 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93310 BRD-K73319509 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93351 BRD-K73319509 MDAMB231 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
93414 BRD-K73319509 NPC 0.37 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
93442 BRD-K73319509 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93509 BRD-K73319509 SKL 3.33 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
93537 BRD-K73319509 THP1 0.12 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
134353 BRD-K73319509 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134379 BRD-K73319509 A549 0.03 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
134404 BRD-K73319509 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134432 BRD-K73319509 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134468 BRD-K73319509 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134511 BRD-K73319509 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134570 BRD-K73319509 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134654 BRD-K73319509 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.24 0.83 0.12
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).