CMap Candidate Details

Structure:
CMap ID: C25766
Pert ID: BRD-K73440166
Compound Name: cinaciguat
Targets: GUCY1B1
MoA: Guanylate cyclase activator
SMILES: OC(=O)CCCCN(CCc1ccccc1OCc1ccc(CCc2ccccc2)cc1)Cc1ccc(cc1)C(O)=O
InchiKey: WPYWMXNXEZFMAK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127378 BRD-K73440166 A375 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
127407 BRD-K73440166 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127455 BRD-K73440166 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127546 BRD-K73440166 JURKAT 0.04 uM 24 h -0.34 -1.42 1.43 0.0 0.0 0.0
127633 BRD-K73440166 PC3 1.11 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
127719 BRD-K73440166 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135386 BRD-K73440166 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135425 BRD-K73440166 HT29 2.22 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
135459 BRD-K73440166 MCF10A 0.01 uM 24 h 0.26 1.09 0.22 0.21 0.74 0.03
135488 BRD-K73440166 MCF??7.00 0.01 uM 24 h -0.34 -1.41 1.42 -0.33 -1.1 0.88
135514 BRD-K73440166 THP1 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).