CMap Candidate Details

Structure:
CMap ID: C25808
Pert ID: BRD-K73541271
Compound Name: etofenamate
Targets: PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor
SMILES: OCCOCCOC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F
InchiKey: XILVEPYQJIOVNB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
51847 BRD-K73541271 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127007 BRD-K73541271 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127086 BRD-K73541271 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127126 BRD-K73541271 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127175 BRD-K73541271 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127197 BRD-K73541271 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127265 BRD-K73541271 THP1 3.33 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
127304 BRD-K73541271 YAPC 10 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
135027 BRD-K73541271 A549 0.74 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.73
135071 BRD-K73541271 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135094 BRD-K73541271 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135159 BRD-K73541271 JURKAT 2.22 uM 24 h 0.25 1.06 0.19 -0.29 -0.97 0.45
135244 BRD-K73541271 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).