CMap Candidate Details

Structure:
CMap ID: C25866
Pert ID: BRD-K73709114
Compound Name: BRD-K73709114
Targets: GBA
MoA: Glucosylceramidase inhibitor
SMILES: Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1nc(nc2ccccc12)-c1cccs1
InchiKey: RGSRXYPOTJVNAZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
13862 BRD-K73709114 A375 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
14324 BRD-K73709114 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
14668 BRD-K73709114 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.14
15125 BRD-K73709114 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
15391 BRD-K73709114 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
15830 BRD-K73709114 PC3 10 uM 6 h -0.2 -0.84 0.01 -0.24 -0.79 0.11
16120 BRD-K73709114 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
115170 BRD-K73709114 U2OS 20 uM 6 h 0.0 0.0 0.0 0.22 0.78 0.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).