CMap Candidate Details

Structure:
CMap ID: C25963
Pert ID: BRD-K74065929
Compound Name: doramapimod
Targets: MAPK14; MAPK11; MAPK12
MoA: P38 MAPK inhibitor
SMILES: Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
InchiKey: MVCOAUNKQVWQHZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91830 BRD-K74065929 HS578T 2.22 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.37
91949 BRD-K74065929 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
92939 BRD-K74065929 ASC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.9
93003 BRD-K74065929 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93091 BRD-K74065929 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93176 BRD-K74065929 HEPG2 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93229 BRD-K74065929 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93283 BRD-K74065929 JURKAT 10 uM 24 h -0.24 -1.0 0.15 -0.28 -0.95 0.4
93421 BRD-K74065929 NPC 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.58
93450 BRD-K74065929 PC3 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
93514 BRD-K74065929 SKL 0.37 uM 24 h -0.22 -0.92 0.06 0.23 0.82 0.1
95340 BRD-K74065929 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95437 BRD-K74065929 U2OS 10 uM 48 h 0.0 0.0 0.0 -0.26 -0.89 0.26
127009 BRD-K74065929 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127088 BRD-K74065929 HELA 10 uM 24 h 0.27 1.14 0.32 0.37 1.31 1.59
127128 BRD-K74065929 HT29 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
127178 BRD-K74065929 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.41 2.02
127199 BRD-K74065929 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127268 BRD-K74065929 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127305 BRD-K74065929 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135074 BRD-K74065929 HA1E 2.22 uM 24 h 0.23 0.95 0.07 0.0 0.0 0.0
135247 BRD-K74065929 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).