CMap Candidate Details

Structure:
CMap ID: C25987
Pert ID: BRD-K74133369
Compound Name: oligomycin-a
Targets: ATP5F1A
MoA: ATPase inhibitor; ATP synthase inhibitor
SMILES: CC[C@H]1CC[C@@H]2O[C@]3(CC[C@@H](C)[C@@H](C[C@@H](C)O)O3)[C@H](C)[C@H](OC(=O)C=C[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@@](C)(O)[C@H](O)[C@@H](C)CC=CC=C1)[C@H]2C
InchiKey: MNULEGDCPYONBU-JBMMDCLPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29938 BRD-K74133369 A375 10 uM 6 h -0.2 -0.83 0.0 -0.36 -1.23 1.25
30107 BRD-K74133369 A549 10 uM 24 h 0.17 0.7 0.0 -0.4 -1.36 2.02
30543 BRD-K74133369 ASC 10 uM 24 h 0.23 0.96 0.08 -0.4 -1.36 2.02
30835 BRD-K74133369 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.66
31126 BRD-K74133369 HCC515 10 uM 6 h 0.0 0.0 0.0 0.23 0.82 0.09
31439 BRD-K74133369 HEPG2 10 uM 6 h -0.3 -1.26 0.71 -0.53 -1.79 15.65
31740 BRD-K74133369 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32068 BRD-K74133369 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32230 BRD-K74133369 NEU 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.83
32518 BRD-K74133369 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32674 BRD-K74133369 PC3 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
33127 BRD-K74133369 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33504 BRD-K74133369 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.28
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).